CIRS is often acquired through different mechanisms, for example, an exposure to environmental sources of biotoxins or chronic illness from Lyme disease present even after treatment with antibiotics. The exposure to environmental sources of biotoxins includes a chronic exposure to the interior environment of water-damaged buildings (WDB) or ingestion of fish contaminated with the toxins of marine dinoflagellates, such as ciguatoxins.
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Patients with CIRS are often misdiagnosed as having depression, stress, allergy, fibromyalgia, post-traumatic stress disorder, Chronic Fatigue Syndrome somatization, etc, and are treated with various therapies, some of which have not yet been shown to be effective and are costly. The reason CIRS is misdiagnosed is because there are no clinical tests to provide confirmatory diagnosis. Our research focuses on a comprehensive approach consisting of a medical evaluation for a number of symptom parameters, such as fatigue, joint pain, short term memory loss, accompanied by a proteogenomic analysis of peripheral blood. The proteogenomic analysis for the diagnosis, treatment, and monitoring of CIRS is based on identifying proteins and/or genes that are differentially expressed in subjects suffering from CIRS compared to healthy subjects.
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Through our research, the expression of several proteins and genes has shown persistent abnormalities in patients suffering from this syndrome.
Changing the way we diagnose
Progenome LLC, is a contract research organization dedicated to the study of chronic, inflammatory disease, with emphasis on diagnosis, treatment, and monitoring of chronic inflammatory response syndrome (CIRS).
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